[HTML][HTML] Oct-1 and CCAAT/enhancer-binding protein (C/EBP) bind to overlapping elements within the interleukin-8 promoter: the role of Oct-1 as a transcriptional …
Interleukin-8 (IL-8), a potent neutrophil chemoattractant, can be expressed at high levels by
many different cell types after immune stimulation. In contrast, expression of IL-8 in these
same cells is virtually absent in the unstimulated state, demonstrating the tight regulation of
the IL-8 gene. Although much is known about how this gene is transcriptionally activated
after immune stimulation, little is known about the regulation of the IL-8 promoter in the
absence of immune activation. In this study we examine how the IL-8 promoter is …
many different cell types after immune stimulation. In contrast, expression of IL-8 in these
same cells is virtually absent in the unstimulated state, demonstrating the tight regulation of
the IL-8 gene. Although much is known about how this gene is transcriptionally activated
after immune stimulation, little is known about the regulation of the IL-8 promoter in the
absence of immune activation. In this study we examine how the IL-8 promoter is …