[HTML][HTML] IKK/NF-κB signaling: balancing life and death–a new approach to cancer therapy

JL Luo, H Kamata, M Karin - The Journal of clinical …, 2005 - Am Soc Clin Investig
JL Luo, H Kamata, M Karin
The Journal of clinical investigation, 2005Am Soc Clin Investig
IκB kinase/NF-κB (IKK/NF-κB) signaling pathways play critical roles in a variety of
physiological and pathological processes. One function of NF-κB is promotion of cell survival
through induction of target genes, whose products inhibit components of the apoptotic
machinery in normal and cancerous cells. NF-κB can also prevent programmed necrosis by
inducing genes encoding antioxidant proteins. Regardless of mechanism, many cancer
cells, of either epithelial or hematopoietic origin, use NF-κB to achieve resistance to …
IκB kinase/NF-κB (IKK/NF-κB) signaling pathways play critical roles in a variety of physiological and pathological processes. One function of NF-κB is promotion of cell survival through induction of target genes, whose products inhibit components of the apoptotic machinery in normal and cancerous cells. NF-κB can also prevent programmed necrosis by inducing genes encoding antioxidant proteins. Regardless of mechanism, many cancer cells, of either epithelial or hematopoietic origin, use NF-κB to achieve resistance to anticancer drugs, radiation, and death cytokines. Hence, inhibition of IKK-driven NF-κB activation offers a strategy for treatment of different malignancies and can convert inflammation-induced tumor growth to inflammation-induced tumor regression.
The Journal of Clinical Investigation