[HTML][HTML] Transforming Growth Factor-β (TGF-β)-induced Down-regulation of Cyclin A Expression Requires a Functional TGF-β Receptor Complex …
XH Feng, EH Filvaroff, R Derynck - Journal of Biological Chemistry, 1995 - ASBMB
Transforming growth factor-β (TGF-β) inhibits the proliferation of epithelial cells by altering
the expression or function of various components of the cell cycle machinery. Expression of
one of these components, cyclin A, is inhibited by TGF-β treatment. We have identified a 760-
base pair fragment of the human cyclin A gene promoter that is sufficient to confer TGF-β
responsiveness. Using this promoter fragment, we have developed a cyclin A-based
luciferase reporter assay that quantitates the growth inhibitory effect of TGF-β in transient …
the expression or function of various components of the cell cycle machinery. Expression of
one of these components, cyclin A, is inhibited by TGF-β treatment. We have identified a 760-
base pair fragment of the human cyclin A gene promoter that is sufficient to confer TGF-β
responsiveness. Using this promoter fragment, we have developed a cyclin A-based
luciferase reporter assay that quantitates the growth inhibitory effect of TGF-β in transient …