Synergistic stimulatory effect of glucagon-like peptide-1 (7–36) amide and glucose-dependent insulin-releasing polypeptide on the endocrine rat pancreas
HC Fehmann, B Göke, R Göke, ME Trautmann… - FEBS letters, 1989 - Elsevier
HC Fehmann, B Göke, R Göke, ME Trautmann, R Arnold
FEBS letters, 1989•ElsevierThe interaction of glucagon-like peptide-1 (7–36) amide (GLP-1) and glucose-dependent
insulin-releasing polypeptide (GIP) on insulin release from the perfused rat pancreas was
studied. The GLP-1 stimulated (0.5 nmol/l), glucose-induced (6.7 mmol/l) insulin secretory
answer was enhanced by GIP (0.1, 1.0 and 10.0 nmol/l) to the arterial perfusate. This effect
was maximal at 1 nmol/l GIP and smaller but still significant at 0.1 nmol/l GIP. The high GIP
concentration of 10 nmol/l GIP did not further increase insulin secretion compared to the …
insulin-releasing polypeptide (GIP) on insulin release from the perfused rat pancreas was
studied. The GLP-1 stimulated (0.5 nmol/l), glucose-induced (6.7 mmol/l) insulin secretory
answer was enhanced by GIP (0.1, 1.0 and 10.0 nmol/l) to the arterial perfusate. This effect
was maximal at 1 nmol/l GIP and smaller but still significant at 0.1 nmol/l GIP. The high GIP
concentration of 10 nmol/l GIP did not further increase insulin secretion compared to the …
Abstract
The interaction of glucagon-like peptide-1 (7–36)amide (GLP-1) and glucose-dependent insulin-releasing polypeptide (GIP) on insulin release from the perfused rat pancreas was studied. The GLP- 1 stimulated (0.5 nmol/l), glucose-induced (6.7 mmol/l) insulin secretory answer was enhanced by GIP (0.1, 1.0 and 10.0 nmol/l) to the arterial perfusate. This effect was maximal at 1 nmol/l GIP and smaller but still significant at 0.1 nmol/l GIP. The high GIP concentration of 10 nmol/l GIP did not further increase insulin secretion compared to the stimulation by 1 nmol/l GIP. Our data demonstrate an additive synergistic effect of GLP- 1 and GIP on the glucose-induced insulin release. This supports the concept of an action ‘in concert’ of gastrointestinal incretin hormones postprandially released on the endocrine pancreas to guarantee adequate insulin answers after meals.
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