[HTML][HTML] RIP-Cre revisited, evidence for impairments of pancreatic β-cell function
The Cre/loxP recombinase system for performing conditional gene targeting experiments
has been very useful in exploring genetic pathways that control both the development and
function of pancreatic β-cells. One particular line of transgenic mice (B6. Cg-Tg (Ins2-cre)
25Mgn/J), commonly called RIP-Cre, in which expression of Cre recombinase is controlled
by a short fragment of the rat insulin II gene promoter has been used in at least 21 studies on
at least 17 genes. In most of these studies inactivation of the gene of interest was associated …
has been very useful in exploring genetic pathways that control both the development and
function of pancreatic β-cells. One particular line of transgenic mice (B6. Cg-Tg (Ins2-cre)
25Mgn/J), commonly called RIP-Cre, in which expression of Cre recombinase is controlled
by a short fragment of the rat insulin II gene promoter has been used in at least 21 studies on
at least 17 genes. In most of these studies inactivation of the gene of interest was associated …