Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) are associated with
skeletal muscle complaints, including clinically important myositis and rhabdomyolysis, mild
serum creatine kinase (CK) elevations, myalgia with and without elevated CK levels, muscle
weakness, muscle cramps, and persistent myalgia and CK elevations after statin withdrawal.
We performed a literature review to provide a clinical summary of statin-associated
myopathy and discuss possible mediating mechanisms. We also update the US Food and …