Defective CD4T cell priming and resistance to experimental autoimmune encephalomyelitis in TNF-deficient mice due to innate immune hypo-responsiveness
G Kassiotis, K Kranidioti, G Kollias - Journal of neuroimmunology, 2001 - Elsevier
We report here that tumor necrosis factor (TNF) deficiency causes innate hypo-
responsiveness to a broad range of bacterial or viral constituents. In vivo hypo-
responsiveness of TNF-deficient mice to mycobacteria results in defective CD4+ T cell
priming to antigens administered in complete Freund's adjuvant (CFA). This deficiency is
restored by supplementary mycobacteria. Furthermore, we show that even when self-
reactive CD4+ T cell priming is fully restored, susceptibility of TNF-deficient mice to …
responsiveness to a broad range of bacterial or viral constituents. In vivo hypo-
responsiveness of TNF-deficient mice to mycobacteria results in defective CD4+ T cell
priming to antigens administered in complete Freund's adjuvant (CFA). This deficiency is
restored by supplementary mycobacteria. Furthermore, we show that even when self-
reactive CD4+ T cell priming is fully restored, susceptibility of TNF-deficient mice to …