β-Cell death during progression to diabetes
D Mathis, L Vence, C Benoist - Nature, 2001 - nature.com
D Mathis, L Vence, C Benoist
Nature, 2001•nature.comThe hallmark of type 1 diabetes is specific destruction of pancreatic islet β-cells. Apoptosis of
β-cells may be crucial at several points during disease progression, initiating leukocyte
invasion of the islets and terminating the production of insulin in islet cells. β-Cell apoptosis
may also be involved in the occasional evolution of type 2 into type 1 diabetes.
β-cells may be crucial at several points during disease progression, initiating leukocyte
invasion of the islets and terminating the production of insulin in islet cells. β-Cell apoptosis
may also be involved in the occasional evolution of type 2 into type 1 diabetes.
Abstract
The hallmark of type 1 diabetes is specific destruction of pancreatic islet β-cells. Apoptosis of β-cells may be crucial at several points during disease progression, initiating leukocyte invasion of the islets and terminating the production of insulin in islet cells. β-Cell apoptosis may also be involved in the occasional evolution of type 2 into type 1 diabetes.
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