Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D
The regulation of the phosphaturic factor fibroblast growth factor 23 (FGF23) is not well
understood. It was found that administration of 1, 25-dihydroxyvitamin D 3 (1, 25 [OH] 2 D 3)
to mice rapidly increased serum FGF23 concentrations from a basal level of 90.6±8.1 to
213.8±14.6 pg/ml at 8 h (mean±SEM; P< 0.01) and resulted in a four-fold increase in FGF23
transcripts in bone, the predominate site of FGF23 expression. In the Hyp-mouse homologue
of X-linked hypophosphatemic rickets, administration of 1, 25 (OH) 2 D 3 further increased …
understood. It was found that administration of 1, 25-dihydroxyvitamin D 3 (1, 25 [OH] 2 D 3)
to mice rapidly increased serum FGF23 concentrations from a basal level of 90.6±8.1 to
213.8±14.6 pg/ml at 8 h (mean±SEM; P< 0.01) and resulted in a four-fold increase in FGF23
transcripts in bone, the predominate site of FGF23 expression. In the Hyp-mouse homologue
of X-linked hypophosphatemic rickets, administration of 1, 25 (OH) 2 D 3 further increased …