Increased Parathyroid Hormone Gene Expression in Secondary Hyperparathyroidism of Experimental Uremia Is Reversed by Calcimimetics: Correlation with …
R Levi, IZ Ben-Dov, V Lavi-Moshayoff… - Journal of the …, 2006 - journals.lww.com
Most patients with chronic kidney disease develop secondary hyperparathyroidism with
disabling systemic complications. Calcimimetic agents are effective tools in the management
of secondary hyperparathyroidism, acting through allosteric modification of the calcium-
sensing receptor (CaR) on the parathyroid gland (PT) to decrease parathyroid hormone
(PTH) secretion and PT cell proliferation. This study showed that rats that were fed an
adenine high-phosphorus diet had increased serum PTH and PTH mRNA levels at 7 and 21 …
disabling systemic complications. Calcimimetic agents are effective tools in the management
of secondary hyperparathyroidism, acting through allosteric modification of the calcium-
sensing receptor (CaR) on the parathyroid gland (PT) to decrease parathyroid hormone
(PTH) secretion and PT cell proliferation. This study showed that rats that were fed an
adenine high-phosphorus diet had increased serum PTH and PTH mRNA levels at 7 and 21 …