The ß-glucuronidase klotho hydrolyzes and activates the TRPV5 channel
Q Chang, S Hoefs, AW Van Der Kemp, CN Topala… - Science, 2005 - science.org
Q Chang, S Hoefs, AW Van Der Kemp, CN Topala, RJ Bindels, JG Hoenderop
Science, 2005•science.orgBlood calcium concentration is maintained within a narrow range despite large variations in
dietary input and body demand. The Transient Receptor Potential ion channel TRPV5 has
been implicated in this process. We report here that TRPV5 is stimulated by the mammalian
hormone klotho. Klotho, a β-glucuronidase, hydrolyzes extracellular sugar residues on
TRPV5, entrapping the channel in the plasma membrane. This maintains durable calcium
channel activity and membrane calcium permeability in kidney. Thus, klotho activates a cell …
dietary input and body demand. The Transient Receptor Potential ion channel TRPV5 has
been implicated in this process. We report here that TRPV5 is stimulated by the mammalian
hormone klotho. Klotho, a β-glucuronidase, hydrolyzes extracellular sugar residues on
TRPV5, entrapping the channel in the plasma membrane. This maintains durable calcium
channel activity and membrane calcium permeability in kidney. Thus, klotho activates a cell …
Blood calcium concentration is maintained within a narrow range despite large variations in dietary input and body demand. The Transient Receptor Potential ion channel TRPV5 has been implicated in this process. We report here that TRPV5 is stimulated by the mammalian hormone klotho. Klotho, a β-glucuronidase, hydrolyzes extracellular sugar residues on TRPV5, entrapping the channel in the plasma membrane. This maintains durable calcium channel activity and membrane calcium permeability in kidney. Thus, klotho activates a cell surface channel by hydrolysis of its extracellular N-linked oligosaccharides.
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