NALPs: a novel protein family involved in inflammation
J Tschopp, F Martinon, K Burns - Nature reviews Molecular cell biology, 2003 - nature.com
J Tschopp, F Martinon, K Burns
Nature reviews Molecular cell biology, 2003•nature.comA newly discovered family of cytoplasmic proteins—the NALPs—has been implicated in the
activation of caspase-1 by the Toll-like receptors (TLRs) during the cell's response to
microbial infection. Like the structurally related apoptotic protease-activating factor-1 (APAF-
1), which is responsible for the activation of caspase-9, the NALP1 protein forms a large,
signal-induced multiprotein complex, the inflammasome, resulting in the activation of pro-
inflammatory caspases.
activation of caspase-1 by the Toll-like receptors (TLRs) during the cell's response to
microbial infection. Like the structurally related apoptotic protease-activating factor-1 (APAF-
1), which is responsible for the activation of caspase-9, the NALP1 protein forms a large,
signal-induced multiprotein complex, the inflammasome, resulting in the activation of pro-
inflammatory caspases.
Abstract
A newly discovered family of cytoplasmic proteins — the NALPs — has been implicated in the activation of caspase-1 by the Toll-like receptors (TLRs) during the cell's response to microbial infection. Like the structurally related apoptotic protease-activating factor-1 (APAF-1), which is responsible for the activation of caspase-9, the NALP1 protein forms a large, signal-induced multiprotein complex, the inflammasome, resulting in the activation of pro-inflammatory caspases.
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