[HTML][HTML] Regulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase Cδ
SC Frasch, PM Henson, JM Kailey, DA Richter… - Journal of Biological …, 2000 - ASBMB
Phospholipid scramblase induces nonspecific bidirectional movement of phospholipids
across the membrane during cell activation and has been proposed to mediate the
appearance of phosphatidylserine (PS) in the plasma membrane outer leaflet during
apoptosis, a cell surface change that is critical for apoptotic cell removal. We report here that
protein kinase C (PKC) δ plays an important role in activated transbilayer movement of
phospholipids and surface PS exposure by directly enhancing the activity of phospholipid …
across the membrane during cell activation and has been proposed to mediate the
appearance of phosphatidylserine (PS) in the plasma membrane outer leaflet during
apoptosis, a cell surface change that is critical for apoptotic cell removal. We report here that
protein kinase C (PKC) δ plays an important role in activated transbilayer movement of
phospholipids and surface PS exposure by directly enhancing the activity of phospholipid …