[HTML][HTML] Synergistic cooperation between hypoxia and transforming growth factor-β pathways on human vascular endothelial growth factor gene expression
T Sánchez-Elsner, LM Botella, B Velasco… - Journal of Biological …, 2001 - ASBMB
Signaling by transforming growth factor (TGF)-β family members is mediated by Smad
proteins that regulate gene transcription through functional cooperativity and association
with other DNA-binding proteins. The hypoxia-inducible factor (HIF)-1 is a transcriptional
complex that plays a key role in oxygen-regulated gene expression. We demonstrate that
hypoxia and TGF-β cooperate in the induction of the promoter activity of vascular endothelial
growth factor (VEGF), which is a major stimulus in the promotion of angiogenesis. This …
proteins that regulate gene transcription through functional cooperativity and association
with other DNA-binding proteins. The hypoxia-inducible factor (HIF)-1 is a transcriptional
complex that plays a key role in oxygen-regulated gene expression. We demonstrate that
hypoxia and TGF-β cooperate in the induction of the promoter activity of vascular endothelial
growth factor (VEGF), which is a major stimulus in the promotion of angiogenesis. This …