How do we avoid developing allergy: modifications of the TH2 response from a B-cell perspective
RC Aalberse, TAE Platts-Mills - Journal of allergy and clinical immunology, 2004 - Elsevier
The synthesis of IgE by B cells occurs at a low rate compared with that of other antibodies,
even in allergic subjects. One rate-limiting step is the class switch, by which B lymphocytes
switch to produce immunoglobulin ε heavy chains rather than μ or γ heavy chains. We
propose an additional rate-limiting step: survival of the B lymphocyte after the switch to IgE.
The hypothesis we present here is that the survival of the IgE-switched B cell is
compromised, particularly in an active germinal center. Antigenic stimulation in the absence …
even in allergic subjects. One rate-limiting step is the class switch, by which B lymphocytes
switch to produce immunoglobulin ε heavy chains rather than μ or γ heavy chains. We
propose an additional rate-limiting step: survival of the B lymphocyte after the switch to IgE.
The hypothesis we present here is that the survival of the IgE-switched B cell is
compromised, particularly in an active germinal center. Antigenic stimulation in the absence …