Elevated serum levels of interleukin-12 in chronic progressive multiple sclerosis
F Nicoletti, F Patti, C Cocuzza, P Zaccone… - Journal of …, 1996 - Elsevier
The serum levels of the heterodimeric cytokine IL-12 were measured by solid-phase ELISA
in a group of healthy subjects, multiple sclerosis (MS) patients with secondary chronic
progressive course of the disease and patients suffering from other neurological diseases
(OND) Serum levels of IL-12 higher than 5 pg/ml (limit of sensitivity of the assay) were only
found in 2/30 (6.7%) of the healthy subjects and none of the 8 subjects with OND. In contrast,
IL-12 was found in the majority of CPMS patients' sera (10/15, 66.7%) with values ranging …
in a group of healthy subjects, multiple sclerosis (MS) patients with secondary chronic
progressive course of the disease and patients suffering from other neurological diseases
(OND) Serum levels of IL-12 higher than 5 pg/ml (limit of sensitivity of the assay) were only
found in 2/30 (6.7%) of the healthy subjects and none of the 8 subjects with OND. In contrast,
IL-12 was found in the majority of CPMS patients' sera (10/15, 66.7%) with values ranging …