Manipulation of the Th1/Th2 balance in autoimmune disease
LB Nicholson, VK Kuchroo - Current opinion in immunology, 1996 - Elsevier
LB Nicholson, VK Kuchroo
Current opinion in immunology, 1996•ElsevierMany autoimmune diseases are caused by autopathogenic Th1 cells. Because in vitro Th1
and Th2 cells cross-regulate each other, it is likely that the induction of self-antigen-specific
Th2 cells can prevent autoimmune disease. In the past year, investigators have further
defined the role of Th1 and Th2 cytokines in the induction and regulation of autoimmunity.
Furthermore, the role of MHC—antigen—T-cell avidity (strength of signal) in inducing such
protective immune responses has been elucidated.
and Th2 cells cross-regulate each other, it is likely that the induction of self-antigen-specific
Th2 cells can prevent autoimmune disease. In the past year, investigators have further
defined the role of Th1 and Th2 cytokines in the induction and regulation of autoimmunity.
Furthermore, the role of MHC—antigen—T-cell avidity (strength of signal) in inducing such
protective immune responses has been elucidated.
Many autoimmune diseases are caused by autopathogenic Th1 cells. Because in vitro Th1 and Th2 cells cross-regulate each other, it is likely that the induction of self-antigen-specific Th2 cells can prevent autoimmune disease. In the past year, investigators have further defined the role of Th1 and Th2 cytokines in the induction and regulation of autoimmunity. Furthermore, the role of MHC—antigen—T-cell avidity (strength of signal) in inducing such protective immune responses has been elucidated.
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