Cutting edge: IL-10-producing CD4+ T cells mediate tumor rejection
BM Segal, DD Glass, EM Shevach - The journal of Immunology, 2002 - journals.aai.org
BM Segal, DD Glass, EM Shevach
The journal of Immunology, 2002•journals.aai.orgIL-10 has potent immunosuppressive properties, and IL-10-producing CD4+ Tr1 cells have
been characterized as regulators of Th1-mediated immunity. In this study, using a sc model
of glioma cell growth in mice, we demonstrate that CD4+, but not CD8+, T cells play a critical
role in tumor rejection following vaccination with irradiated glioma cells. Surprisingly, glioma-
specific CD4+ T cells produce IL-10 but neither IL-4 nor IFN-γ, and glioma rejection is
compromised in IL-10−/− hosts. Hence, our findings demonstrate that IL-10-producing CD4+ …
been characterized as regulators of Th1-mediated immunity. In this study, using a sc model
of glioma cell growth in mice, we demonstrate that CD4+, but not CD8+, T cells play a critical
role in tumor rejection following vaccination with irradiated glioma cells. Surprisingly, glioma-
specific CD4+ T cells produce IL-10 but neither IL-4 nor IFN-γ, and glioma rejection is
compromised in IL-10−/− hosts. Hence, our findings demonstrate that IL-10-producing CD4+ …
Abstract
IL-10 has potent immunosuppressive properties, and IL-10-producing CD4+ Tr1 cells have been characterized as regulators of Th1-mediated immunity. In this study, using a sc model of glioma cell growth in mice, we demonstrate that CD4+, but not CD8+, T cells play a critical role in tumor rejection following vaccination with irradiated glioma cells. Surprisingly, glioma-specific CD4+ T cells produce IL-10 but neither IL-4 nor IFN-γ, and glioma rejection is compromised in IL-10−/− hosts. Hence, our findings demonstrate that IL-10-producing CD4+ T cells can manifest antitumor functions and suggest that IL-10 may have proinflammatory effects in disease states.
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