Publisher Summary This chapter reveals how nitric oxide (NO) generated by the inducible
isoform of nitric oxide synthase (iNOS) exerts multiple beneficial microbicidal, antiviral,
antiparasital, complex immunomodulatory, and antitumoral effects. Aberrant iNOS induction
in the wrong place or at the wrong time has detrimental consequences and it is involved in
the pathophysiology of several human diseases. Therefore, iNOS has to be regulated very
tightly. The inducible isoform of NOS is mainly regulated at the level of expression. The …

The role of nitric oxide (NO) generated by the inducible isoform of nitric oxide synthase
(iNOS) is very complex. Induction of iNOS expression and hence NO production has been
described to have beneficial antiviral, antiparasital, microbicidal, immunomodulatory, and
antitumoral effects. However, induced at the wrong place or at the wrong time, iNOS has
detrimental consequences and seems to be involved in the pathophysiology of different
human diseases. The pathways regulating iNOS expression seem to vary in different cells or …