Surgical excision combined with autologous whole tumor cell vaccination is an effective therapy for murine neuroblastoma
K Ohashi, G Kobayashi, S Fang, X Zhu… - Journal of pediatric …, 2006 - Elsevier
BACKGROUND: Although a whole tumor cell vaccine strategy based on the synergistic
action of granulocyte macrophage–colony-stimulating factor (GM-CSF) transduced tumor
cells and CpG oligodeoxynucleotides induces potent tumor-specific immunity, such therapy
is not curative in the face of large established tumors. PURPOSE: The primary goal of this
study was to determine if combining surgical resection of the tumor with whole tumor cell
vaccination is an effective therapeutic strategy for established neuroblastoma. We also …
action of granulocyte macrophage–colony-stimulating factor (GM-CSF) transduced tumor
cells and CpG oligodeoxynucleotides induces potent tumor-specific immunity, such therapy
is not curative in the face of large established tumors. PURPOSE: The primary goal of this
study was to determine if combining surgical resection of the tumor with whole tumor cell
vaccination is an effective therapeutic strategy for established neuroblastoma. We also …