[HTML][HTML] STARS, a striated muscle activator of Rho signaling and serum response factor-dependent transcription

A Arai, JA Spencer, EN Olson - Journal of Biological Chemistry, 2002 - ASBMB
Changes in actin dynamics influence diverse cellular processes and couple the actin-based
cytoskeleton to changes in gene transcription. Members of the Rho GTPase family regulate
cytoskeletal organization by stimulating actin polymerization and stress fiber formation when
activated by extracellular signaling. The transcriptional activity of serum response factor
(SRF) is stimulated in response to changes in actin dynamics and Rho signaling, but the
proteins that mediate this phenomenon have not been fully identified. We describe a novel …