Targeting plasmid‐encoded proteins to the antigen presentation pathways
JA Leifert, MP Rodriguez‐Carreno… - Immunological …, 2004 - Wiley Online Library
JA Leifert, MP Rodriguez‐Carreno, F Rodriguez, J Lindsay Whitton
Immunological reviews, 2004•Wiley Online LibraryThe antigen presentation pathways constitute a fulcrum on which adaptive immunity is
balanced, and their manipulation should allow us to induce designer immune responses.
The ease and rapidity with which DNA vaccines can be constructed and altered make them
ideal candidates with which to test the various targeting strategies that have been conceived
to date. These approaches and the mechanisms that may (or may not) underlie their success
are reviewed in this article.
balanced, and their manipulation should allow us to induce designer immune responses.
The ease and rapidity with which DNA vaccines can be constructed and altered make them
ideal candidates with which to test the various targeting strategies that have been conceived
to date. These approaches and the mechanisms that may (or may not) underlie their success
are reviewed in this article.
Summary
The antigen presentation pathways constitute a fulcrum on which adaptive immunity is balanced, and their manipulation should allow us to induce designer immune responses. The ease and rapidity with which DNA vaccines can be constructed and altered make them ideal candidates with which to test the various targeting strategies that have been conceived to date. These approaches and the mechanisms that may (or may not) underlie their success are reviewed in this article.
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