Depletion of CD4+ CD25+ regulatory cells augments the generation of specific immune T cells in tumor-draining lymph nodes
H Tanaka, J Tanaka, J Kjaergaard… - Journal of …, 2002 - journals.lww.com
Recent studies have identified a unique population of CD4+ CD25+ regulatory T cells that is
crucial for the prevention of spontaneous autoimmune diseases. Further studies
demonstrated that depletion of CD4+ CD25+ T cells enhances immune responses to nonself
antigens. Because immune responses to malignant tumors are weak and ineffective,
depletion of regulatory T cells has been reported to result in tumor regression. In the current
study, using the weakly immunogenic MCA205 sarcoma and the poorly immunogenic …
crucial for the prevention of spontaneous autoimmune diseases. Further studies
demonstrated that depletion of CD4+ CD25+ T cells enhances immune responses to nonself
antigens. Because immune responses to malignant tumors are weak and ineffective,
depletion of regulatory T cells has been reported to result in tumor regression. In the current
study, using the weakly immunogenic MCA205 sarcoma and the poorly immunogenic …