Interleukin-10: a cytokine used by tumors to escape immunosurveillance
F Salazar-Onfray - Medical oncology, 1999 - Springer
Medical oncology, 1999•Springer
The mechanisms whereby malignant cells can elude the recognition of the immune system,
by what is termed 'immunological escape', have attracted major attention of tumor
immunologists during the past decade. In this review, the role of the immunosuppressive
cytokine interleukin-10 (IL-10) will be discussed as a strategy used by tumors to avoid
recognition by cytotoxic T lymphocytes (CTL).
by what is termed 'immunological escape', have attracted major attention of tumor
immunologists during the past decade. In this review, the role of the immunosuppressive
cytokine interleukin-10 (IL-10) will be discussed as a strategy used by tumors to avoid
recognition by cytotoxic T lymphocytes (CTL).
Abstract
The mechanisms whereby malignant cells can elude the recognition of the immune system, by what is termed ‘immunological escape’, have attracted major attention of tumor immunologists during the past decade. In this review, the role of the immunosuppressive cytokine interleukin-10 (IL-10) will be discussed as a strategy used by tumors to avoid recognition by cytotoxic T lymphocytes (CTL).
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