Cyclophosphamide and other new agents for the treatment of severe aplastic anemia
JF Tisdale, DE Dunn, J Maciejewski - Seminars in hematology, 2000 - Elsevier
Severe aplastic anemia (SAA) has a poor prognosis in the absence of treatment. Current
accepted therapeutic strategies include allogeneic stem-cell transplantation and
immunosuppression, both resulting in long-term survival in the majority of patients. Although
human leukocyte antigen (HLA)-matched sibling stem-cell transplantation is highly effective,
the 25% probability of finding a suitable sibling donor within a family renders this approach
available to only a minority of patients. Transplantation using HLA-matched, unrelated …
accepted therapeutic strategies include allogeneic stem-cell transplantation and
immunosuppression, both resulting in long-term survival in the majority of patients. Although
human leukocyte antigen (HLA)-matched sibling stem-cell transplantation is highly effective,
the 25% probability of finding a suitable sibling donor within a family renders this approach
available to only a minority of patients. Transplantation using HLA-matched, unrelated …