The regulatory role of Vα14 NKT cells in innate and acquired immune response
M Taniguchi, M Harada, S Kojo… - Annual review of …, 2003 - annualreviews.org
M Taniguchi, M Harada, S Kojo, T Nakayama, H Wakao
Annual review of immunology, 2003•annualreviews.orgA novel lymphocyte lineage, Vα14 natural killer T (NKT) cells, is now well established as
distinct from conventional αβ T cells. Vα14 NKT cells express a single invariant Vα14
antigen receptor that is essential for their development. Successful identification of a specific
ligand, α-galactosylceramide (α-GalCer), and the establishment of gene-manipulated mice
with selective loss of Vα14 NKT cells helped elucidate the remarkable functional diversity of
Vα14 NKT cells in various immune responses such as host defense by mediating anti …
distinct from conventional αβ T cells. Vα14 NKT cells express a single invariant Vα14
antigen receptor that is essential for their development. Successful identification of a specific
ligand, α-galactosylceramide (α-GalCer), and the establishment of gene-manipulated mice
with selective loss of Vα14 NKT cells helped elucidate the remarkable functional diversity of
Vα14 NKT cells in various immune responses such as host defense by mediating anti …
A novel lymphocyte lineage, Vα14 natural killer T (NKT) cells, is now well established as distinct from conventional αβ T cells. Vα14 NKT cells express a single invariant Vα14 antigen receptor that is essential for their development. Successful identification of a specific ligand, α-galactosylceramide(α-GalCer), and the establishment of gene-manipulated mice with selective loss of Vα14 NKT cells helped elucidate the remarkable functional diversity of Vα14 NKT cells in various immune responses such as host defense by mediating anti-nonself innate immune reaction, homeostatic regulation of anti-self responses, and antitumor immunity.
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