[HTML][HTML] K-and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

DB Whyte, P Kirschmeier, TN Hockenberry… - Journal of Biological …, 1997 - ASBMB
The association of mutant forms of Ras protein with a variety of human cancers has
stimulated intense interest in therapies based on inhibiting oncogenic Ras signaling.
Attachment of Ras proteins to the plasma membrane is required for effective Ras signaling
and is initiated by the enzyme farnesyl protein transferase. We found that in the presence of
potent farnesyl protein transferase inhibitors, Ras proteins in the human colon carcinoma
cell line DLD-1 were alternatively prenylated by geranylgeranyl transferase-1. When H-Ras …