Antifungal activity of a Candida albicans GGTase I inhibitor-alanine conjugate. Inhibition of Rho1p prenylation in C. albicans
KK Murthi, SE Smith, AF Kluge, G Bergnes… - Bioorganic & medicinal …, 2003 - Elsevier
KK Murthi, SE Smith, AF Kluge, G Bergnes, P Bureau, V Berlin
Bioorganic & medicinal chemistry letters, 2003•ElsevierAn alanine conjugate of a Candida albicans geranylgeranyl transferase I inhibitor was
synthesized to facilitate its uptake into the fungal cell. The antifungal activity of CaGGTase-
Ala conjugate is demonstrated. It is also shown that the CaGGTase-Ala conjugate affects
prenylation of endogenous Rho1p, but has no effect on prenylation of endogenous Ras1p.
synthesized to facilitate its uptake into the fungal cell. The antifungal activity of CaGGTase-
Ala conjugate is demonstrated. It is also shown that the CaGGTase-Ala conjugate affects
prenylation of endogenous Rho1p, but has no effect on prenylation of endogenous Ras1p.
An alanine conjugate of a Candida albicans geranylgeranyl transferase I inhibitor was synthesized to facilitate its uptake into the fungal cell. The antifungal activity of CaGGTase-Ala conjugate is demonstrated. It is also shown that the CaGGTase-Ala conjugate affects prenylation of endogenous Rho1p, but has no effect on prenylation of endogenous Ras1p.
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