Ca2+/CaM-Dependent Kinases: From Activation to Function
SS Hook, AR Means - Annual review of pharmacology and …, 2001 - annualreviews.org
SS Hook, AR Means
Annual review of pharmacology and toxicology, 2001•annualreviews.orgCalmodulin (CaM) is an essential protein that serves as a ubiquitous intracellular receptor
for Ca2+. The Ca2+/CaM complex initiates a plethora of signaling cascades that culminate
in alteration of cellular functions. Among the many Ca2+/CaM-binding proteins to be
discovered, the multifunctional protein kinases CaMKI, II, and IV play pivotal roles. Our
review focuses on this class of CaM kinases to illustrate the structural and biochemical basis
for Ca2+/CaM interaction with and regulation of its target enzymes. Gene transcription has …
for Ca2+. The Ca2+/CaM complex initiates a plethora of signaling cascades that culminate
in alteration of cellular functions. Among the many Ca2+/CaM-binding proteins to be
discovered, the multifunctional protein kinases CaMKI, II, and IV play pivotal roles. Our
review focuses on this class of CaM kinases to illustrate the structural and biochemical basis
for Ca2+/CaM interaction with and regulation of its target enzymes. Gene transcription has …
Calmodulin (CaM) is an essential protein that serves as a ubiquitous intracellular receptor for Ca2+. The Ca2+/CaM complex initiates a plethora of signaling cascades that culminate in alteration of cellular functions. Among the many Ca2+/CaM-binding proteins to be discovered, the multifunctional protein kinases CaMKI, II, and IV play pivotal roles. Our review focuses on this class of CaM kinases to illustrate the structural and biochemical basis for Ca2+/CaM interaction with and regulation of its target enzymes. Gene transcription has been chosen as the functional endpoint to illustrate the recent advances in Ca2+/CaM-mediated signal transduction mechanisms.
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