[HTML][HTML] Leptin receptor (OB-R) signaling: cytoplasmic domain mutational analysis and evidence for receptor homo-oligomerization
DW White, KK Kuropatwinski, R Devos… - Journal of Biological …, 1997 - ASBMB
The leptin receptor (OB-R) mediates the weight regulatory effects of the adipocyte secreted
hormone leptin (OB). Previously we have shown that the long form of OB-R, expressed
predominantly in the hypothalamus, can mediate ligand-induced activation of signal
transducer and activator of transcription factors 1, 3, and 5 and stimulate transcription via
interleukin-6 and hematopoietin receptor responsive gene elements. Here we report that
deletion and tyrosine substitution mutagenesis of OB-R identifies two distinct regions of the …
hormone leptin (OB). Previously we have shown that the long form of OB-R, expressed
predominantly in the hypothalamus, can mediate ligand-induced activation of signal
transducer and activator of transcription factors 1, 3, and 5 and stimulate transcription via
interleukin-6 and hematopoietin receptor responsive gene elements. Here we report that
deletion and tyrosine substitution mutagenesis of OB-R identifies two distinct regions of the …