[HTML][HTML] Mutant presenilins disturb neuronal calcium homeostasis in the brain of transgenic mice, decreasing the threshold for excitotoxicity and facilitating long-term …

I Schneider, D Reversé, I Dewachter, L Ris… - Journal of Biological …, 2001 - ASBMB
Mutant human presenilin-1 (PS1) causes an Alzheimer's-related phenotype in the brain of
transgenic mice in combination with mutant human amyloid precursor protein by means of
increased production of amyloid peptides (Dewachter, I., Van Dorpe, J., Smeijers, L., Gilis,
M., Kuiperi, C., Laenen, I., Caluwaerts, N., Moechars, D., Checler, F., Vanderstichele, H. &
Van Leuven, F.(2000) J. Neurosci. 20, 6452–6458) that aggravate plaques and
cerebrovascular amyloid (Van Dorpe, J., Smeijers, L., Dewachter, I., Nuyens, D., Spittaels …