Effect of hyperoxia on vascular endothelial growth factor levels in a wound model
AY Sheikh, JJ Gibson, MD Rollins, HW Hopf… - Archives of …, 2000 - jamanetwork.com
Hypothesis Hyperbaric oxygen (HBO) therapy increases vascular endothelial growth factor
(VEGF) levels in wounds. Design Wounds were monitored for oxygen delivery during HBO
treatment, and wound fluids were analyzed for VEGF and lactate on days 2, 5, and 10
following wounding. Setting Experimental animal model. Interventions Rats were
randomized to HBO therapy and control groups. The HBO therapy was administered for 90
minutes, twice daily with 100% oxygen at 2.1 atmospheres absolute. Treatment was …
(VEGF) levels in wounds. Design Wounds were monitored for oxygen delivery during HBO
treatment, and wound fluids were analyzed for VEGF and lactate on days 2, 5, and 10
following wounding. Setting Experimental animal model. Interventions Rats were
randomized to HBO therapy and control groups. The HBO therapy was administered for 90
minutes, twice daily with 100% oxygen at 2.1 atmospheres absolute. Treatment was …