[HTML][HTML] p38 Mitogen-activated Protein Kinase Pathway Protects Adult Rat Ventricular Myocytes against β-Adrenergic Receptor-stimulated Apoptosis: EVIDENCE FOR …
C Communal, WS Colucci, K Singh - Journal of Biological Chemistry, 2000 - ASBMB
We have shown that stimulation of β-adrenergic receptors (β-AR) by norepinephrine (NE)
increases apoptosis in adult rat ventricular myocytes (ARVMs) via a cAMP-dependent
mechanism that is antagonized by activation of G i protein. The family of mitogen-activated
protein kinases (MAPKs) is involved in the regulation of cardiac myocyte growth and
apoptosis. Here we show that β-AR stimulation activates p38 kinase, c-jun N-terminal
kinases (JNKs), and extracellular signal-regulated kinase (ERK1/2) in ARVMs. Inhibition of …
increases apoptosis in adult rat ventricular myocytes (ARVMs) via a cAMP-dependent
mechanism that is antagonized by activation of G i protein. The family of mitogen-activated
protein kinases (MAPKs) is involved in the regulation of cardiac myocyte growth and
apoptosis. Here we show that β-AR stimulation activates p38 kinase, c-jun N-terminal
kinases (JNKs), and extracellular signal-regulated kinase (ERK1/2) in ARVMs. Inhibition of …