[HTML][HTML] New TCR transgenic model for tracking allospecific CD4 T-cell activation and tolerance in vivo
SE Sandner, AD Salama, SL Houser, E Palmer… - American Journal of …, 2003 - Elsevier
We have developed an adoptive transfer model system to visualize the dynamics of
alloantigen-specific CD4+ T-cell activation in vivo. Using TCR-transgenic (tg) mice reactive
to IA bm12, we studied the clonal expansion and differentiation of alloreactive T cells by
tracking the fate of adoptively transferred TCR-tg CD4+ T cells in syngeneic mice
transplanted with skin grafts expressing IA bm12. Following transplantation, alloantigen-
specific TCR-tg CD4+ T-cell expansion was observed initially in the draining lymph nodes …
alloantigen-specific CD4+ T-cell activation in vivo. Using TCR-transgenic (tg) mice reactive
to IA bm12, we studied the clonal expansion and differentiation of alloreactive T cells by
tracking the fate of adoptively transferred TCR-tg CD4+ T cells in syngeneic mice
transplanted with skin grafts expressing IA bm12. Following transplantation, alloantigen-
specific TCR-tg CD4+ T-cell expansion was observed initially in the draining lymph nodes …