Cytokine knockouts in contact hypersensitivity research
B Wang, C Esche, A Mamelak, I Freed… - Cytokine & growth factor …, 2003 - Elsevier
Contact hypersensitivity (CHS) is a Langerhans cell (LC)-dependent, T cell-mediated
cutaneous immune response. CHS reflects a culmination of LC activities in vivo: uptake of
epicutaneous antigens, migration into lymph nodes, and presentation of antigens to naı̈ve
T cells. Although studies have suggested involvement of the cytokine network in LC
migration and CHS initiation, the in vivo function of individual cytokines remains largely
unknown. Gene targeting technology has made it possible to study in vivo functions of …
cutaneous immune response. CHS reflects a culmination of LC activities in vivo: uptake of
epicutaneous antigens, migration into lymph nodes, and presentation of antigens to naı̈ve
T cells. Although studies have suggested involvement of the cytokine network in LC
migration and CHS initiation, the in vivo function of individual cytokines remains largely
unknown. Gene targeting technology has made it possible to study in vivo functions of …