The influence of dexamethasone (DEX), a synthetic glucocorticoid, on the induction in mice
of Langerhans cell (LC) migration has been investigated. Systemic treatment of mice with
DEX was found to inhibit significantly the ability of a topically applied contact allergen
(oxazolone) to induce the migration of LC from the epidermis and their subsequent
accumulation as dendritic cells (DC) in draining lymph nodes. The stimulation of LC
migration during skin sensitization is dependent upon signals provided by the epidermal …