[PDF][PDF] Adoptive immunotherapy: engineering T cell responses as biologic weapons for tumor mass destruction
WY Ho, JN Blattman, ML Dossett, C Yee… - Cancer cell, 2003 - cell.com
Cancer cell, 2003•cell.com
Adoptive immunotherapy: Engineering T cell responses as biologic weapons for tumor mass
destruction Page 1 developmental pressure to delete or tolerize such T cells. Overexpressed
protein antigens associated with tumorigenicity currently being targeted include the WT1
(Wilms’ tumor) gene in leukemias and various solid tumors (Yamagami et al., 1996), and
HER-2/neu in breast and ovarian cancer (van de Vijver et al., 1987). Aberrant expression in
tumors of proteins found only in normal tissues perceived as immune-privileged provides nearly …
destruction Page 1 developmental pressure to delete or tolerize such T cells. Overexpressed
protein antigens associated with tumorigenicity currently being targeted include the WT1
(Wilms’ tumor) gene in leukemias and various solid tumors (Yamagami et al., 1996), and
HER-2/neu in breast and ovarian cancer (van de Vijver et al., 1987). Aberrant expression in
tumors of proteins found only in normal tissues perceived as immune-privileged provides nearly …
Abstract
Adoptive T cell immunotherapy is an evolving technology with the potential of providing a means to safely and effectively target tumor cells for destruction.
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