Adoptive immunotherapy of breast cancer with lymph node cells primed by cryoablation of the primary tumor

MS Sabel, A Arora, G Su, AE Chang - Cryobiology, 2006 - Elsevier
Cryoablation of cancer leaves tumor-associated antigens intact in an inflammatory
microenvironment that can stimulate a regional anti-tumor immune response. We examined
whether cryoablated tumor draining lymph nodes (CTDLN) as adoptive immunotherapy may
be an effective immunotherapeutic approach in the adjuvant treatment of breast cancer.
BALB/c mice with MT-901 mammary adenocarcinoma tumors underwent cryoablation,
resection or no treatment and tumor draining lymph nodes were harvested. Cryoablation …