Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity
Y Echelard, DJ Epstein, B St-Jacques, L Shen… - Cell, 1993 - cell.com
Cell, 1993•cell.com
We have identified three members of a mouse gene family related to the Drosophila
segment polarity gene, hedgehog (h/t). Like h/t, they encode putative secreted proteins and
are thus implicated in cell-cell interactions. One of these, Sonic hh (Shh), is expressed in the
notochord, the floor plate, and the zone of polarizing activity, signaling centers that are
thought to mediate central nervous system (CNS) and limb polarity. Ectopic expression of
Shh in the mouse CNS leads to the activation of floor plate-expressed genes. These results …
segment polarity gene, hedgehog (h/t). Like h/t, they encode putative secreted proteins and
are thus implicated in cell-cell interactions. One of these, Sonic hh (Shh), is expressed in the
notochord, the floor plate, and the zone of polarizing activity, signaling centers that are
thought to mediate central nervous system (CNS) and limb polarity. Ectopic expression of
Shh in the mouse CNS leads to the activation of floor plate-expressed genes. These results …
Summary
We have identified three members of a mouse gene family related to the Drosophila segment polarity gene, hedgehog (h/t). Like h/t, they encode putative secreted proteins and are thus implicated in cell-cell interactions. One of these, Sonic hh (Shh), is expressed in the notochord, the floor plate, and the zone of polarizing activity, signaling centers that are thought to mediate central nervous system (CNS) and limb polarity. Ectopic expression of Shh in the mouse CNS leads to the activation of floor plate-expressed genes. These results suggest that Shh may play a role in the normal inductive interactions that pattern the ventral CNS.
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