UDP-GlcNAc 2-epimerase: a regulator of cell surface sialylation

OT Keppler, S Hinderlich, J Langner… - Science, 1999 - science.org
OT Keppler, S Hinderlich, J Langner, R Schwartz-Albiez, W Reutter, M Pawlita
Science, 1999science.org
Modification of cell surface molecules with sialic acid is crucial for their function in many
biological processes, including cell adhesion and signal transduction. Uridine diphosphate-
N-acetylglucosamine 2-epimerase (UDP-GlcNAc 2-epimerase) is an enzyme that catalyzes
an early, rate-limiting step in the sialic acid biosynthetic pathway. UDP-GlcNAc 2-epimerase
was found to be a major determinant of cell surface sialylation in human hematopoietic cell
lines and a critical regulator of the function of specific cell surface adhesion molecules.
Modification of cell surface molecules with sialic acid is crucial for their function in many biological processes, including cell adhesion and signal transduction. Uridine diphosphate-N-acetylglucosamine 2-epimerase (UDP-GlcNAc 2-epimerase) is an enzyme that catalyzes an early, rate-limiting step in the sialic acid biosynthetic pathway. UDP-GlcNAc 2-epimerase was found to be a major determinant of cell surface sialylation in human hematopoietic cell lines and a critical regulator of the function of specific cell surface adhesion molecules.
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