[HTML][HTML] Induction of tenascin-C in cardiac myocytes by mechanical deformation: role of reactive oxygen species
K Yamamoto, QN Dang, SP Kennedy… - Journal of Biological …, 1999 - ASBMB
Mechanical overload may change cardiac structure through angiotensin II-dependent and
angiotensin II-independent mechanisms. We investigated the effects of mechanical strain on
the gene expression of tenascin-C, a prominent extracellular molecule in actively
remodeling tissues, in neonatal rat cardiac myocytes. Mechanical strain induced tenascin-C
mRNA (3.9±0.5-fold, p< 0.01, n= 13) and tenascin-C protein in an amplitude-dependent
manner but did not induce secreted protein acidic and rich in cysteine nor fibronectin …
angiotensin II-independent mechanisms. We investigated the effects of mechanical strain on
the gene expression of tenascin-C, a prominent extracellular molecule in actively
remodeling tissues, in neonatal rat cardiac myocytes. Mechanical strain induced tenascin-C
mRNA (3.9±0.5-fold, p< 0.01, n= 13) and tenascin-C protein in an amplitude-dependent
manner but did not induce secreted protein acidic and rich in cysteine nor fibronectin …