Tumor necrosis factor-[alpha] inhibits insulin-induced increase in endothelial nitric oxide synthase and reduces insulin receptor content and phosphorylation in human …
Insulin exerts a vasodilatory effect through the release of nitric oxide (NO) from the
endothelium. We have recently demonstrated that insulin also inhibits the expression of
intracellular adhesion molecule-1 (ICAM-1) and monocyte chemoattractant protein-1 (MCP-
1), 2 major proinflammatory mediators, by human aortic endothelial cells (HAEC) and the
proinflammatory mediator, nuclear factor (NF-[kappa] B), in the nucleus in parallel with an
increase in endothelial nitric oxide synthase (e-NOS) expression. The inhibition of ICAM-1 …
endothelium. We have recently demonstrated that insulin also inhibits the expression of
intracellular adhesion molecule-1 (ICAM-1) and monocyte chemoattractant protein-1 (MCP-
1), 2 major proinflammatory mediators, by human aortic endothelial cells (HAEC) and the
proinflammatory mediator, nuclear factor (NF-[kappa] B), in the nucleus in parallel with an
increase in endothelial nitric oxide synthase (e-NOS) expression. The inhibition of ICAM-1 …