[HTML][HTML] Increased β-oxidation but no insulin resistance or glucose intolerance in mice lacking adiponectin
K Ma, A Cabrero, PK Saha, H Kojima, L Li… - Journal of Biological …, 2002 - ASBMB
Previous reports showed that recombinant fragments of adiponectin (adipo) displayed
pharmacological effects when injected into rodents, but the relevance of these observations
to the physiological function of adipo is unclear. We generatedAdipo−/− mice by gene
targeting. Adipo−/− mice are fertile with normal body and fat pad weights. Plasma glucose
and insulin levels ofAdipo−/− and Adipo+/+ mice are similar under fasting conditions and
during an intraperitoneal glucose tolerance test (GTT). Insulin tolerance test (ITT) also …
pharmacological effects when injected into rodents, but the relevance of these observations
to the physiological function of adipo is unclear. We generatedAdipo−/− mice by gene
targeting. Adipo−/− mice are fertile with normal body and fat pad weights. Plasma glucose
and insulin levels ofAdipo−/− and Adipo+/+ mice are similar under fasting conditions and
during an intraperitoneal glucose tolerance test (GTT). Insulin tolerance test (ITT) also …