[HTML][HTML] Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing
T Goswami, NC Andrews - Journal of Biological Chemistry, 2006 - ASBMB
HFE and transferrin receptor 2 (TFR2) are membrane proteins integral to mammalian iron
homeostasis and associated with human hereditary hemochromatosis. Here we
demonstrate that HFE and TFR2 interact in cells, that this interaction is not abrogated by
disease-associated mutations of HFE and TFR2, and that TFR2 competes with TFR1 for
binding to HFE. We propose a new model for the mechanism of iron status sensing that
results in the regulation of iron homeostasis.
homeostasis and associated with human hereditary hemochromatosis. Here we
demonstrate that HFE and TFR2 interact in cells, that this interaction is not abrogated by
disease-associated mutations of HFE and TFR2, and that TFR2 competes with TFR1 for
binding to HFE. We propose a new model for the mechanism of iron status sensing that
results in the regulation of iron homeostasis.