Publisher Summary This chapter discusses the advances made in understanding the
mechanisms of action of chemical carcinogens in the light of the recent evidence that
oncogenes are directly implicated in the process of tumor development. It discusses various
model systems used to address the question of cell transformation in vivo. The process of
carcinogenesis in cell culture is compared with the various stages of tumor development in
vivo. It is noted that oncogenes provide potential targets for activation by carcinogens …