Haemoglobin Hammersmith (β 42 (CD1) Phe→ Ser)
JV Dacie, NK Shinton, PJ Gaffney, RW Carrell… - Nature, 1967 - nature.com
JV Dacie, NK Shinton, PJ Gaffney, RW Carrell, H Lehmann
Nature, 1967•nature.comThe forty-second amino-acid of the β-chain of human haemoglobin and its equivalent in all
known globins (CD1) is phenylalanine; it stabilizes the haem by direct contact. In
Haemoglobin Hammersmith, replacement by serine causes instability of the molecule and
thereby severe haemolytic Heinz body anaemia.
known globins (CD1) is phenylalanine; it stabilizes the haem by direct contact. In
Haemoglobin Hammersmith, replacement by serine causes instability of the molecule and
thereby severe haemolytic Heinz body anaemia.
Abstract
The forty-second amino-acid of the β-chain of human haemoglobin and its equivalent in all known globins (CD1) is phenylalanine; it stabilizes the haem by direct contact. In Haemoglobin Hammersmith, replacement by serine causes instability of the molecule and thereby severe haemolytic Heinz body anaemia.
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