[HTML][HTML] Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer
The mammalian CYP1A1, CYP1A2, and CYP1B1 genes (encoding cytochromes P450 1A1,
1A2, and 1B1, respectively) are regulated by the aromatic hydrocarbon receptor (AHR). The
CYP1 enzymes are responsible for both metabolically activating and detoxifying numerous
polycyclic aromatic hydrocarbons (PAHs) and aromatic amines present in combustion
products. Many substrates for CYP1 enzymes are AHR ligands. Differences in AHR affinity
between inbred mouse strains reflect variations in CYP1 inducibility and clearly have been …
1A2, and 1B1, respectively) are regulated by the aromatic hydrocarbon receptor (AHR). The
CYP1 enzymes are responsible for both metabolically activating and detoxifying numerous
polycyclic aromatic hydrocarbons (PAHs) and aromatic amines present in combustion
products. Many substrates for CYP1 enzymes are AHR ligands. Differences in AHR affinity
between inbred mouse strains reflect variations in CYP1 inducibility and clearly have been …