The insulin gene in type 1 diabetes
A Pugliese - IUBMB life, 2005 - Wiley Online Library
A Pugliese
IUBMB life, 2005•Wiley Online LibraryInsulin is a key autoantigen in the autoimmune process leading to the development of type 1
diabetes. Recent studies in both humans and mice have shown that variation in the
expression of the insulin gene, in the thymus rather than the pancreas, contributes to
disease susceptibility by affecting self‐tolerance to insulin. These findings have brought
about a paradigm‐shift in our understanding of self‐tolerance and autoimmunity to
molecules with tissue‐restricted expression, which are often the target of autoimmune …
diabetes. Recent studies in both humans and mice have shown that variation in the
expression of the insulin gene, in the thymus rather than the pancreas, contributes to
disease susceptibility by affecting self‐tolerance to insulin. These findings have brought
about a paradigm‐shift in our understanding of self‐tolerance and autoimmunity to
molecules with tissue‐restricted expression, which are often the target of autoimmune …
Abstract
Insulin is a key autoantigen in the autoimmune process leading to the development of type 1 diabetes. Recent studies in both humans and mice have shown that variation in the expression of the insulin gene, in the thymus rather than the pancreas, contributes to disease susceptibility by affecting self‐tolerance to insulin. These findings have brought about a paradigm‐shift in our understanding of self‐tolerance and autoimmunity to molecules with tissue‐restricted expression, which are often the target of autoimmune disease. IUBMB Life, 57: 463‐468, 2005
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