[HTML][HTML] Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor
JL Babitt, Y Zhang, TA Samad, Y Xia, J Tang… - Journal of Biological …, 2005 - ASBMB
Bone morphogenetic proteins (BMPs) are members of the transforming growth factor β (TGF-
β) superfamily of ligands, which regulate many mammalian physiologic and
pathophysiologic processes. BMPs exert their effects through type I and type II
serine/threonine kinase receptors and the Smad intracellular signaling pathway. Recently,
the glycosylphosphatidylinositol (GPI)-anchored protein DRAGON was identified as a co-
receptor for BMP signaling. Here, we investigate whether a homologue of DRAGON …
β) superfamily of ligands, which regulate many mammalian physiologic and
pathophysiologic processes. BMPs exert their effects through type I and type II
serine/threonine kinase receptors and the Smad intracellular signaling pathway. Recently,
the glycosylphosphatidylinositol (GPI)-anchored protein DRAGON was identified as a co-
receptor for BMP signaling. Here, we investigate whether a homologue of DRAGON …