[HTML][HTML] Activated protein C reduces stress‐induced gastric mucosal injury in rats by inhibiting the endothelial cell injury
H Isobe, K Okajima, N Harada, W Liu… - Journal of Thrombosis and …, 2004 - Elsevier
Background and objective: Activated protein C (APC) is a natural anticoagulant with anti‐
inflammatory activity. APC inhibits neutrophil activation through inhibition of tumor necrosis
factor (TNF)‐α production. Such anti‐inflammatory activity of APC has recently been shown
to be critical in the treatment of patients with severe sepsis. We previously demonstrated that
activated neutrophils play a crucial role in the development of stress‐induced gastric
mucosal injury. Thus, inhibition of neutrophil activation by APC should reduce endothelial …
inflammatory activity. APC inhibits neutrophil activation through inhibition of tumor necrosis
factor (TNF)‐α production. Such anti‐inflammatory activity of APC has recently been shown
to be critical in the treatment of patients with severe sepsis. We previously demonstrated that
activated neutrophils play a crucial role in the development of stress‐induced gastric
mucosal injury. Thus, inhibition of neutrophil activation by APC should reduce endothelial …